Fishing the Targets of Bioactive Compounds from Psidium guajava L. Leaves in the Context of Diabetes by Elixabet Díaz-de-Cerio 1,†, Francisco Girón 2,†, Alfonso Pérez-Garrid
Author/s
Girón, Francisco; Pérez Garrido, Alfonso; Pereira, Andreia; Gabaldón, José Antonio; Verado, Vito; [et al.]Date
2023-03-17Discipline/s
Ciencias de la AlimentaciónMedicina
Subject/s
Psidium guajava L.Phenolic Compounds
Leaves
In silico
Guava
Diabetes mellitus
Abstract
Psidium guajava L. (guava) leaves have demonstrated their in vitro and in vivo effect against diabetes mellitus (DM). However, there is a lack of literature concerning the effect of the individual phenolic compounds present in the leaves in DM disease. The aim of the present work was to identify the individual compounds in Spanish guava leaves and their potential contribution to the observed anti-diabetic effect. Seventy-three phenolic compounds were identified from an 80% ethanol extract of guava leaves by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry. The potential anti-diabetic activity of each compound was evaluated with the DIA-DB web server that uses a docking and molecular shape similarity approach. The DIA-DB web server revealed that aldose reductase was the target protein with heterogeneous affinity for compounds naringenin, avicularin, guaijaverin, quercetin, ellagic acid, morin, catechin and guavinos...