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dc.contributor.authorStelling Férez, Javier
dc.contributor.authorLópez Miranda, Santiago
dc.contributor.authorGabaldón, José Antonio
dc.contributor.authorNicolás, Francisco José
dc.date.accessioned2024-07-04T09:52:02Z
dc.date.available2024-07-04T09:52:02Z
dc.date.issued2023-10-03
dc.identifier.citationStelling-Férez, J.; López-Miranda, S.; Gabaldón, J.A.; Nicolás, F.J. Oleanolic Acid Complexation with Cyclodextrins Improves Its Cell Bio-Availability and Biological Activities for Cell Migration. Int. J. Mol. Sci. 2023, 24, 14860. https://doi.org/ 10.3390/ijms241914860es
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10952/7923
dc.description.abstractWound healing is a complex process to restore skin. Plant-derived bioactive compounds might be a source of substances for the treatment of wounds stalled in a non-resolving stage of wound healing. Oleanolic acid (OA), a pentacyclic triterpene, has shown favorable wound healing properties both in vitro and in vivo. Unfortunately, OA cannot be solubilized in aqueous media, and it needs to be helped by the use of dimethyl sulfoxide (DMSO). In this paper, we have shown that cyclodextrins (CDs) are a good alternative to DMSO as agents to deliver OA to cells, providing better features than DMSO. Cyclodextrins are natural macromolecules that show a unique tridimensional structure that can encapsulate a wide variety of hydrophobic compounds. We have studied the cyclodextrin-encapsulated form of OA with OA/DMSO, comparing their stability, biological properties for cell migration, and cell viability. In addition, detailed parameters related to cell migration and cytoskeletal reorganization have been measured and compared. Our results show that OA-encapsulateds compound exhibit several advantages when compared to non-encapsulated OA in terms of chemical stability, migration enhancement, and preservation of cell viability.es
dc.language.isoenes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMAP kinaseses
dc.subjectEpidermal growth factor receptor (EGR)es
dc.subjectCell migrationes
dc.subjectOleanolic acid (OA)es
dc.subjectHydroxypropyl cyclodextrins (HP-CDs)es
dc.subjectWound healinges
dc.subjectc-Junes
dc.titleOleanolic Acid Complexation with Cyclodextrins Improves Its Cell Bio-Availability and Biological Activities for Cell Migrationes
dc.typearticlees
dc.rights.accessRightsopenAccesses
dc.relation.projectIDPI17/02164 and PI21/01339es
dc.journal.titleInternational Journal of Molecular Scienceses
dc.volume.number24es
dc.issue.number1486es
dc.description.disciplineMedicinaes
dc.identifier.doi10.3390/ijms241914860es


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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