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Effectiveness of Consumption of a Combination of Citrus Fruit Flavonoids and Olive Leaf Polyphenols to Reduce Oxidation of Low-Density Lipoprotein in Treatment-Naïve Cardiovascular Risk Subjects: A Randomized Double-Blind Controlled Study
dc.contributor.author | Victoria Montesinos, Desirée | |
dc.contributor.author | Abellán Ruiz, María Salud | |
dc.contributor.author | Luque Rubia, Antonio J. | |
dc.contributor.author | Guillén Martínez, Daniel | |
dc.contributor.author | Pérez Piñero, Silvia | |
dc.contributor.author | Sánchez Macarro, Maravillas | |
dc.contributor.author | García Muñoz, Ana María | |
dc.contributor.author | Cánovas García, Fernando | |
dc.contributor.author | Castillo Sánchez, Julián | |
dc.contributor.author | López Román, Francisco Javier | |
dc.date.accessioned | 2024-06-17T06:58:54Z | |
dc.date.available | 2024-06-17T06:58:54Z | |
dc.date.issued | 2021-04-11 | |
dc.identifier.uri | http://hdl.handle.net/10952/7826 | |
dc.description.abstract | The aim of the study was to assess whether oral intake of a nutraceutical product (Citrolive™) could determine changes in low-density lipoprotein (LDL) oxidation and other parameters of lipid metabolism and plasma atherogenic capacity. Citrolive™ is a commercial extract obtained from the combination of citrus fruit flavonoids and olive leaf extracts. Twenty-three untreated subjects (69.6% males, 30.4% females, mean age 41.9 ± 9.4 years) with cardiovascular risk factors and a total cholesterol level >200 mg/dL and LDL cholesterol (LDL-C) > 130 mg/dL participated in a 3-month randomized double-blind controlled study. Participants in the intervention group (71.4% males, 28.6% females, mean age 42.7 ± 9.7 years) consumed Citrolive™ (500 mg, two capsules/day), and controls (66.7% males, 33.3% females, mean age 40.6 ± 9.4 years) received a matched placebo. At 3 months, oxidized LDL (ox-LDL) decreased significantly in the intervention group from 93.8 ± 19.1 U/L to 62.8 ± 28.7 U/L (p < 0.05), whereas the control group increased from 98.2 ± 23.5 U/L to 105.7 ± 21.9 U/L (p = 0.1). Between-group differences were also significant (p < 0.05). Similar findings in the ox-LDL/LDL-C ratio were observed. Serum paraoxonase activity (PON1) increased significantly in the intervention group from 64.5 ± 15.6 U/L to 78.7 ± 28.8 U/L (p < 0.05) but remained unchanged in controls. Consumption of Citrolive™ for 3 months in treatment-naïve subjects with moderate risk of atherosclerosis was associated with a reduction in oxidized LDL-C and LDL-oxidase/LDL-C ratio as compared to controls. | es |
dc.language.iso | en | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Polyphenols | es |
dc.subject | Olive leaf extracts | es |
dc.subject | Oleuropeosides | es |
dc.subject | Food supplements | es |
dc.subject | Flavonoids | es |
dc.subject | Cardiovascular risk | es |
dc.subject | Antioxidant | es |
dc.title | Effectiveness of Consumption of a Combination of Citrus Fruit Flavonoids and Olive Leaf Polyphenols to Reduce Oxidation of Low-Density Lipoprotein in Treatment-Naïve Cardiovascular Risk Subjects: A Randomized Double-Blind Controlled Study | es |
dc.type | article | es |
dc.rights.accessRights | openAccess | es |
dc.description.discipline | Ciencias de la Alimentación | es |
dc.identifier.doi | 10.3390/antiox10040589 | es |