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Antioxidant effect of a probiotic product on a model of oxidative stress induced by high-intensity and duration physical exercise
dc.contributor.author | Sánchez Macarro, Maravillas | |
dc.contributor.author | Ávila Gandía, Vicente | |
dc.contributor.author | Pérez Piñero, Silvia | |
dc.contributor.author | Cánovas García, Fernando | |
dc.contributor.author | García Muñoz, Ana María | |
dc.contributor.author | Abellán Ruiz, María Salud | |
dc.contributor.author | Victoria Montesinos, Desirée | |
dc.contributor.author | Luque Rubia, Antonio J. | |
dc.contributor.author | Climent, Eric | |
dc.contributor.author | Genovés, Salvador | |
dc.contributor.author | Ramon, Daniel | |
dc.contributor.author | Chenoll, Empar | |
dc.contributor.author | López Román, Francisco Javier | |
dc.date.accessioned | 2024-06-17T06:42:27Z | |
dc.date.available | 2024-06-17T06:42:27Z | |
dc.date.issued | 2021-02-22 | |
dc.identifier.issn | 2076-3921 | |
dc.identifier.uri | http://hdl.handle.net/10952/7821 | |
dc.description.abstract | This randomized double-blind and controlled single-center clinical trial was designed to evaluate the effect of a 6-week intake of a probiotic product (1 capsule/day) vs. a placebo on an oxidative stress model of physical exercise (high intensity and duration) in male cyclists (probiotic group, n = 22; placebo, n = 21). This probiotic included three lyophilized strains (Bifidobacterium longum CECT 7347, Lactobacillus casei CECT 9104, and Lactobacillus rhamnosus CECT 8361). Study variables were urinary isoprostane, serum malondialdehyde (MDA), serum oxidized low-density lipoprotein (Ox-LDL), urinary 8-hydroxy-2′-deoxiguanosine (8-OHdG), serum protein carbonyl, serum glutathione peroxidase (GPx), and serum superoxide dismutase (SOD). At 6 weeks, as compared with baseline, significant differences in 8-OHdG (Δ mean difference −10.9 (95% CI −14.5 to −7.3); p < 0.001), MDA (Δ mean difference −207.6 (95% CI −349.1 to −66.1; p < 0.05), and Ox-LDL (Δ mean difference −122.5 (95% CI −240 to −4.5); p < 0.05) were found in the probiotic group only. Serum GPx did not increase in the probiotic group, whereas the mean difference was significant in the placebo group (477.8 (95% CI 112.5 to 843.2); p < 0.05). These findings suggest an antioxidant effect of this probiotic on underlying interacting oxidative stress mechanisms and their modulation in healthy subjects. The study was registered in ClinicalTrials.gov (NCT03798821). | es |
dc.language.iso | en | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Oxidative stress | es |
dc.subject | Probiotics | es |
dc.subject | Physical exercise | es |
dc.subject | Male cyclist | es |
dc.subject | Oxidative stress biomarkers | es |
dc.subject | Antioxidative enzymes | es |
dc.title | Antioxidant effect of a probiotic product on a model of oxidative stress induced by high-intensity and duration physical exercise | es |
dc.type | article | es |
dc.rights.accessRights | openAccess | es |
dc.journal.title | Antioxidants | es |
dc.volume.number | 10 | es |
dc.issue.number | 2 | es |
dc.description.discipline | Ciencias de la Alimentación | es |
dc.identifier.doi | 10.3390/antiox10020323 | es |