http://hdl.handle.net/10952/2101 Sat, 27 Jun 2026 15:13:53 GMT 2026-06-27T15:13:53Z http://hdl.handle.net/10952/11070 Metabolic Responses to Exercise and Nutritional Strategies in Type 1 Diabetes Using Automated Insulin Delivery Systems: A Narrative Review Victoria Montesinos, Desirée; Llopis Alonso, Inmaculada; García Muñoz, Ana María; Mercader Ros, María Teresa Background/Objectives: Automated insulin delivery (AID) systems have improved the management of type 1 diabetes (T1D), but exercise and nutrition remain challenging because they rapidly alter glucose flux, substrate oxidation, hepatic glucose output, insulin requirements, and fuel availability. This narrative review aimed to synthesize current evidence on the interaction between AID systems, physical activity, and nutritional strategies from a metabolism-oriented perspective. Methods: A narrative bibliographic approach was used to integrate evidence from clinical trials, observational studies, technical studies, consensus statements, and reviews involving people with T1D across different life stages, including pediatric, adolescent, adult, and pregnancy-related contexts, when available. The review focused on AID systems, exercise physiology, nutritional strategies, meal announcement, bolus adjustment, dual-hormone systems, metabolic biomarkers, and emerging metabolomic approaches. Results: AID systems generally improve time in range and reduce hypoglycemia across several user groups, although most exercise- and nutrition-specific evidence comes from adult and pediatric/adolescent cohorts rather than pregnancy-specific exercise studies. Exercise-related glucose responses remain highly dependent on user input, exercise modality, insulin on board, meal timing, and metabolic state. Planned exercise announcement, prandial bolus reduction before postprandial activity, and individualized carbohydrate intake remain key strategies. Biomarkers such as lactate, ketone bodies, non-esterified fatty acids, and counter-regulatory hormones may help explain interindividual variability and support future personalization. Conclusions: Nutrition and exercise management in AID users should be interpreted as a dynamic metabolic interface among exogenous insulin, endogenous counter-regulation, substrate availability, and algorithmic control. Emerging approaches, including activity sensors, adaptive algorithms, dual-hormone systems, digital twins, and metabolomics-informed personalization, may improve safety and reduce user burden, but several remain exploratory and require further validation in diverse free-living conditions Tue, 23 Jun 2026 00:00:00 GMT http://hdl.handle.net/10952/11070 2026-06-23T00:00:00Z http://hdl.handle.net/10952/11069 Effects of Curcumin Supplementation on Exercise Recovery, Oxidative Stress, Inflammation, Muscle Damage, and Performance in Exercise and Sport Contexts: A Systematic Review Lloret Gil, Jesús; Victoria Montesinos, Desirée; Martínez Noguera, Francisco Javier Background/Objectives: Curcumin has been proposed as a nutritional strategy to support exercise recovery through antioxidant and anti-inflammatory actions. However, trials differ in sport context, training status, supplementation timing, dose, formulation, and methodological control. This systematic review evaluated its effects on recovery outcomes in active individuals and athletes, with particular attention to the applicability of the evidence to real-world sport settings. Methods: PubMed, Scopus, Web of Science, SPORTDiscus, and Cochrane Library/CENTRAL were searched from 2012 to June 2026. Randomized double-blind placebo-controlled trials were eligible when they evaluated oral curcumin, curcuminoids, Curcuma-derived preparations with a specified curcumin dose, or curcumin combined only with bioavailability enhancers. Studies using artificial muscle-damage protocols, clinical populations, non-randomized designs, or combined bioactive interventions were excluded. Methodological quality was assessed using the Physiotherapy Evidence Database (PEDro) scale, supplemented by a Cochrane Risk of Bias 2 (RoB 2) assessment and a Grading of Recommendations Assessment, Development and Evaluation (GRADE) certainty-of-evidence evaluation. Owing to heterogeneity, findings were synthesized narratively by outcome domain, supplementation timing, formulation type, exercise context, and training status. Results: Fifteen trials were included. Favorable effects were reported in 6/7 studies assessing oxidative stress, 4/6 assessing muscle damage, 3/8 assessing inflammation, 3/7 assessing subjective recovery, soreness, or fatigue, and 4/8 assessing physical or athletic performance. However, effects varied substantially according to population, exercise context, biomarker selection, timing of assessment, and formulation type. The certainty of evidence was low for oxidative stress and very low for muscle damage, inflammation, subjective recovery/soreness/fatigue, and performance. Conclusions: Curcumin supplementation may support selected aspects of exercise recovery, particularly oxidative stress responses. However, these findings should be interpreted cautiously because the evidence derives mostly from small trials with heterogeneous populations, exercise protocols, supplementation regimens, formulations, biomarkers, and assessment time points. Evidence for muscle damage, inflammation, subjective recovery, fatigue, and performance remains inconsistent, and further well-controlled trials in trained and high-performance athletes are needed before practical recommendations can be established. Fri, 19 Jun 2026 00:00:00 GMT http://hdl.handle.net/10952/11069 2026-06-19T00:00:00Z http://hdl.handle.net/10952/11044 Acute Moderate-Dose β-Alanine Improves Exercise Efficiency via Bicarbonate-Related Mechanisms During a Cycling Time Trial Muñoz Carrillo, Juan Carlos; Pérez Piñero, Silvia; Lopez Roman, Javier; Luque Rubia, Antonio Jesús; Ávila Gandía, Vicente Background: Research on the acute effects of β-alanine supplementation has primarily focused on performance outcomes, with limited attention to the underlying physiological mechanisms. This study aimed to investigate the acute effects of two β-alanine doses on performance, mechanical output, and acid–base balance during a 10 min cycling time trial (10’-TT), and to explore the relationship between buffering-related variables and performance. Methods: Eighty-five recreational cyclists performed a 10’-TT under indoor conditions before (control) and following the acute ingestion of β-alanine (moderate-dose β-alanine 10 g—BAM; high-dose β-alanine 20 g—BAH) or placebo (PLA), with each condition tested on separate days. Data were analyzed using two-way repeated-measures ANOVA and correlation analyses. Results: No significant differences were observed in performance variables (distance, speed, cadence, or heart rate; p ≥ 0.751). However, total external mechanical work (kJ) was significantly reduced following acute supplementation (p = 0.028). Notably, the BAM condition reduced the mechanical cost of exercise without impairing performance, and this effect was moderately associated with changes in bicarbonate levels. Conclusions: Acute β-alanine supplementation did not improve performance outcomes but may alter buffering-related physiological responses associated with reduced mechanical work during high-intensity cycling exercise. These findings highlight the relevance of buffering-related mechanisms, particularly bicarbonate dynamics, in modulating the mechanical cost (work performed relative to performance achieved) of high-intensity exercise. Sat, 20 Jun 2026 00:00:00 GMT http://hdl.handle.net/10952/11044 2026-06-20T00:00:00Z http://hdl.handle.net/10952/11043 The Ethos And Essence Of Palliative Medicine: A Comprehensive Review Garcia-Baquero Merino, Maria Teresa; Menárguez, Micaela; Segarra, Ignacio Palliative medicine(PM)is anapproach that merges professional knowledge with ethical and emotional sensibility to help patients dealing with a serious illness.This review highlights two related featuresessence and ethosthat influence palliative practice. The essence refers to the commitment to reducing suffering and the willingness to embrace life itself, while the ethos reflects the moral and humanistic idealscompassion, dignity, and respect for autonomythat shape how care is rendered. This paper does not suggest a dualistic framework;rather,it uses Cicely Sanders’s Heart and Mind idea to suggest that they are mutually reinforcing and correspond closely with each other. The analysis shows that ethos and essence are not opposing tensions, but rather complementary features of a unified philosophy of care. After reviewing historical developments, ethical principles, and clinical models, the review illustrates how values and practices reinforce each other, leading to palliative care that is more equitable, responsive, and person-centered. The integrated approach creates technically good care systems, while being deeply humane to ensure patients receive care in ways that honour their physical, emotional, and existential needs. Overall, the research suggests that the values of palliative care delivery are in congruence with clinical realisation of carein numerous settings. Sat, 10 Jan 2026 00:00:00 GMT http://hdl.handle.net/10952/11043 2026-01-10T00:00:00Z